翻訳と辞書 Words near each other ・ Peptidoglycan recognition protein ・ Peptidoglycan-N-acetylglucosamine deacetylase ・ Peptidomimetic ・ Peptidyl transferase ・ Peptidyl-Asp metalloendopeptidase ・ Peptidyl-dipeptidase B ・ Peptidyl-dipeptidase Dcp ・ Peptidyl-glutamate 4-carboxylase ・ Peptidyl-glutaminase ・ Peptidyl-glycinamidase ・ Peptidyl-L-lysine(-L-arginine) hydrolase ・ Peptidyl-Lys metalloendopeptidase ・ Peptidylamidoglycolate lyase ・ Peptidylglycine alpha-amidating monooxygenase ・ Peptidylglycine monooxygenase ・ Peptidylprolyl isomerase A ・ Peptidylprolyl isomerase D ・ Peptitergents ・ Peptization ・ Peptococcaceae ・ Peptococcus ・ Peptoid ・ Peptoid nanosheet ・ Peptoniphilus ・ Peptostreptococcaceae ・ Peptostreptococcus ・ Peptostreptococcus anaerobius ・ Peptostreptococcus asaccharolyticus ・ Pepu Hernández ・ Pepusch Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Peptidylprolyl isomerase A ： ウィキペディア英語版 Peptidylprolyl isomerase A Peptidylprolyl isomerase A (PPIA), also known as cyclophilin A (CypA) or rotamase A is an enzyme that in humans is encoded by the ''PPIA'' gene on chromosome 7.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5478 )〕 As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to regulate many biological processes, including intracellular signaling, transcription, inflammation, and apoptosis.〔 Due to its various functions, PPIA has been implicated in a broad range of inflammatory diseases, including atherosclerosis and arthritis, and viral infections.〔〔〔 ==Structure== PPIA is an 18 kDa, 165-amino acid long cytosolic protein. Like other cyclophilins, PPIA forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti-parallel β-strands and capped by two α-helices at the top and bottom.〔〔 In addition, the β-turns and loops in the strands contribute to the flexibility of the barrel.〔 Its active site is a hydrophobic pocket that binds peptides containing proline. Cyclosporine can bind this pocket to inhibit the protein’s enzymatic activity.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Peptidylprolyl isomerase A」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.